Bromocriptine

• is a dopamine agonist(D2)
• Has extensive first pass metabolism
• it is an ergot derivative , so it may cause gangrene
• used in
  • amenorrhea/galactorrhea due to hyperprolactinemia
  • prolactinoma and hyperprolactinemia
  • to stop lactation
  • DMT2
  • Parkinson’s disease

ADRs:

• Nausea and vomiting,  postural hypotension
• Digital vasospasm and erythromelalgia

after prolonged use

• pleural effusion
• pleural, cardiac & retroperitoneal fibrosis