Which of the following alpha blocker does not induce apoptosis of prostate smooth muscle when used for BPH for long term?

1. Doxazosin
2. Terazosin
3. tamsulosin
4. all of the above

answer: Tamsulosin

ref: GG 13E/P 209

alpha blockers whicht induce apoptosis of prostate smooth muscle when used for BPH for long term are

• Doxazosin
• Terazosin

reason???????

• Doxazosin and Terazosin  contain quinazoline moiety
•  quinazoline moiety  induces apoptosis of prostate smooth muscle
•  apoptosis is not because of α1 receptor antagonism
• tamsulosin
• is nonquinazoline α1 receptor antagonist
• it does not produce apoptosis

NOTE: