Which of the following is false about Pramlinitide?

1. Used in Type 1 and Type 2 DM
2. Acts through Amylin receptor
3. increases insulin release
4. causes weight loss

answer: increases insulin release

ref: GG  13E/P  886

Pramlintide:

acts through the amylin receptor

• reduces glucagon secretion
• delays gastric emptying
• feeling of satiety is seen
• doesn’t increase insulin release

Adverse Effects:

• nausea and hypoglycemia(MC)( when used with insulin)

Therapeutic Uses.:

• approved for treatment of types 1 and 2 diabetes as an adjunct in patients who take insulin with meals

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