Which of the following is incorrect regarding Mexiletine?

1. it is an analogue of Lidocaine
2. cannot be given oral due to high first pass metabolism
3. Tremor and nausea are  the major dose-related adverse effects
4. approved for treating ventricular arrhythmias

answer: 2

Mexiletine:

• is an analogue of lidocaine
• has been modified to reduce first-pass hepatic metabolism and permit chronic oral therapy
• Tremor and nausea, the major dose-related adverse effects, can be minimized by taking the drugs with food
• it is approved for treating ventricular arrhythmias