MOA:

• Potassium channel opener

important points

• antihypertensive, antidiuretic with hyperglycaemic effects

• Related chemically to thiazide diuretics but Causes Na and water retention , so called paradoxical diuretic
• CAUSES
  • hyperuricemia, hyperglycemia and retention of fluid

Uses

• inoperable insulinomas
• in children with neonatal hyperinsulinism
• in hypertensive emergencies