Which of the following statements are true about neostigmine
(a) It is a quartarnary ammounium compound
(b) It is metabolised by liver
(c) It can cross the blood brain barrier
(d) Prominent effect on cardiac muscle
(e) It possess agonistic action on NM receptors

 answer is A and E

KDT 7E/P 107

Neostigmine:

• is a reversible cholinesterase inhibitor
• agonistic action on NM receptors
• quarternary ammonium compound, So it cannot cross blood-brain-barrier
• No Prominent effect on cardiac muscle
• partly hydrolyzed by serum cholinesterase and partly excreted unchanged by the kidneys
• used in
• myasthenia gravis
• Postoperative paralytic ileus
• Postoperative urinary retention
• Postoperative decurarization
• Cobra bite

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