Which of the following anticancer drug causes Cerebellar toxicity  (AIIMS May 2009)

1. Cisplatin
2. Cytarabine
3. Bleomycin
4. Actinomycin D

answer Cytarabine

GG 13E/P1183

Cytarabine causes

• irreversible Cerebellar toxicity
• manifestations are  ataxia and slurred speech, and cerebral toxicity (seizures, dementia, and coma)
• seen after
  • intra thecal administration or high-dose systemic administration
• risk factors
  • older than 40 years or patients with poor renal function

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