Published on Sep 22, 2018
DAILY MCQ 58 answer

atypical antipsychotic drug  with maximum  hyperprolactinemia is

  1. olanzapine
  2. clozapine
  3. ziprasidone
  4. resperidone

ref: GG 12e/ p 423

atypical  antipsychotics agents

  • have decreased affinity for D2 receptors
  • so, hyperprolactinemia adverse effect is reduced in patients
  • but  risperidone and paliperidone are exceptions
  • because both agents cause dose-dependent increases in prolactin

resperidone:

  • Fewer side effects than Clozapine
  • Blocks selective D2, NA  & 5-HT2
  • Becomes "typical" at high doses leading to EPS (>6mg)
  • Long acting injectable formulation
  • Shares sedation, tachycardia, orthostatic hypotension and elevated prolactin
  • No agranulocytosis risks
  • Hyperprolactinemia

note:

among atypical antipsychotics risperidone, paliperidone have high D2 affinity  and blocks it causing Hyperprolactinemia