imipenem :

• is a carbepenem
• activity against gram +ve, gram -ve and anerobes
• imipenem is degraded by renal tubular dipeptidase and duration of action is short
• cilastin inhibits renal tubular dipeptidase and increases imipenem duration of action
• cilastin has no antimicrobial property
• Imipenem + cilastin combination is synergistic
• seizures are seen with high doses
• seizures are seen more  with impenem compared to other carbepenems