Following are Synthetic reactions in biotransformation except

1. Glucuronidation
2. Acetylation
3. Methylation
4. Reduction

answer:  reduction

The classification of biotransformation is given by R.T.WILLIAMS

As PHASE I and PHASE II reaction

PHASE I Reactions:

• Non-synthetic reaction – metabolite may be active or inactive
  • Oxidation
  • Reduction
  • Hydrolysis
  • Cyclization
  • Decyclization
  • hydroxylation (aromatic and aliphatic)

PHASE II Reactions:

• Synthetic/Conjugation reaction – metabolite is  mostly inactive

• Glucuronidation
• Acetylation
• Methylation
• Sulphate
• Glycine
• glutathione 

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