Calculate hepatic clearance of a drug with hepatic blood flow of 1500 ml/min and hepatic extraction ratio of 0.5

1. 1000ml per min
2. 1500ml per min
3. 1125ml per min
4. 750ml per min

answer: 750ml/min

Hepatic  clearance   = hepatic blood flow X hepatic extraction ratio

                           = 1500 x 0.5

                            = 750ml/min

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